PUF4 — Schizosaccharomyces pombe 972h-

Summary

SPAC27F1.04C, also known as PUF4 or nuf2 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein with kinetochore adaptor activity, microtubule binding, and protein complex binding. It is a component of the Ndc80 complex and localizes to the kinetochore, centromere complex, and meiotic spindle pole body. The gene is associated with kinetochore organization and assembly, centromere clustering, spindle checkpoint, microtubule dynamics, meiotic chromosome segregation, and spindle pole body duplication. It has been linked to abnormal cell cycle progression, including increased G1 and S phase duration, decreased sporulation, altered growth rates, abnormal budding and colony morphology, increased prion formation, and decreased mitophagy and pexophagy. Related genes in other species are linked to RNA binding via Pumilio domains and to potassium concentration traits.