pot1 — Schizosaccharomyces pombe 972h-

Summary

SPAC26H5.06 (pot1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes the Pot1 protein, a member of the POT1PC and telomere end-binding POT1/Cdc13 family that contains an NA-bd OB-fold domain. The product exhibits G-rich strand telomeric DNA binding and telomerase inhibitor activity. Pot1 is associated with telomere capping, telomere localization, and regulation of telomere maintenance via telomerase, as well as upregulation of telomere maintenance, strand displacement, and telomeric silencing. It is linked to chromatin silencing, DNA damage checkpoint, double-strand break repair, base excision repair, sumoylation, and cell-cycle processes including prophase, M phase, spindle assembly, spindle chromosome attachment, and the spindle assembly checkpoint. The protein localizes to the nuclear telomere cap complex, telomere cap complex, chromosome telomeric repeat region, cytosol, and nucleus. Studies of related genes in other species further connect it to the telosome.