SID1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23G3.03 (SID1, also known as sib2) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a protein with a Lys/Orn_oxygenase domain and a FAD/NAD-binding superfamily domain. The gene product is an ornithine N5-monooxygenase (EC 1.14.13.196) that also exhibits N,N-dimethylaniline monooxygenase activity, binds NADP+, FAD, iron, and nucleotides. SID1 is associated with ferrichrome and siderophore biosynthesis, iron import into the cell, cellular response to iron starvation, and iron ion homeostasis. It has also been linked to polar cell growth, cell morphogenesis, spore germination, vesicle fusion, mitotic exit, RAM/MOR signaling, the septation initiation network, and dephosphorylation. The protein localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.