TPP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23C11.04C, also known as TPP1 or pnk1, encodes a polynucleotide phosphatase with polynucleotide 3'-phosphatase and ATP-dependent DNA kinase activities, belonging to the HAD-superfamily hydrolase IIIA and P-loop NTPase families. In Schizosaccharomyces pombe, this gene is associated with single-strand break repair, base excision repair, nucleotide excision repair, homologous recombination, interstrand crosslink repair, telomere maintenance and localization, DNA damage checkpoint response, S phase progression, programmed cell death, and hypersensitivity. It has also been linked to respiration rate, sumoylation, mycose metabolism, and DNA anabolism. The product localizes to the nucleolus and nucleus. Studies of related genes in other species connect the family to similar DNA repair and processing functions.