rad4 — Schizosaccharomyces pombe 972h-

Summary

SPAC23C4.18C (rad4) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes the P74 protein, which contains a BRCT domain and is annotated as having signaling adaptor activity and chromatin adaptor function. The gene is associated with response to radiation, replication fork arrest, and multiple checkpoint pathways including the mitotic G2 DNA damage checkpoint, S-M checkpoint, and cell cycle checkpoint. It is linked to nucleotide excision repair (NER), transcription-coupled NER (TC-NER), and UV excision repair (UVER), as well as DNA replication initiation, pre-RC assembly, and DNA metabolism. The protein localizes to chromatin, the nucleus, cytosol, mitotic spindle, spindle pole body, sites of double-strand breaks, and the BRCA1-B complex and pre-initiation complex. Associations with cell cycle control, nuclear division, and M phase further connect rad4 to genome stability and cell cycle regulation.