PP2A — Schizosaccharomyces pombe 972h-

Summary

SPAC22H10.04, also known as PP2A, PPA3 or PPG1, encodes a putative serine/threonine-protein phosphatase with protein phosphatase activity (EC 3.1.3.16) and metal binding, belonging to the PPA2-like and calcineurin-like phosphoprotein phosphatase families. In Schizosaccharomyces pombe, this gene is associated with diverse cellular processes including glucose homeostasis, centromeric sister chromatid cohesion, cell quiescence, septum positioning, spindle positioning, regulation of TORC1 signaling, glycerol anabolism, and negative regulation of the DNA damage checkpoint and the mevalonate pathway. It localizes to the PP2A complex, protein phosphatase 4 complex, SIP complex, centromere complex, nuclear periphery, mitotic spindle pole body, and chromatin. Phenotypic associations include abnormal cell cycle progression, altered pheromone sensitivity, decreased apoptosis, increased mitophagy, decreased pexophagy and reticulophagy, abnormal mitochondrial genome maintenance, and decreased ionic stress resistance.