PAC1 — Schizosaccharomyces pombe 972h-

Summary

SPAC22G7.10, also known as PAC1 or iss1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a pre-mRNA polyadenylation factor fip1 protein with a Fip1 domain and a pre-mRNA 3'-end processing regulatory domain. The product exhibits protein binding (bridging) and RNA binding molecular functions. This gene is associated with cotranscriptional 3' processing of RNA polymerase II mRNA transcripts, nuclear mRNA surveillance of 3'-end processing, RNA surveillance and breakdown, snRNA metabolism, tRNA processing, DNA replication initiation and regulation, chromatin and centromeric silencing, DNA imprinting, mating type switching, meiosis II, cell differentiation, and response to xenobiotic stimulus. It localizes to the nucleus, chromatin, heterochromatin islands, the Mmi1 nuclear focus, and the mRNA cleavage and polyadenylation specificity factor complex. Phenotypically, PAC1 is linked to increased thermotolerance and sporulation, altered cell cycle progression including G1/S and G2/M arrest, increased polyploidy, decreased chromosome segregation, and increased hydrostatic pressure resistance.