ADH — Schizosaccharomyces pombe 972h-

Summary

SPAC22A12.17C (ADH) on chromosome 1 of Schizosaccharomyces pombe encodes an uncharacterized oxidoreductase belonging to the short-chain dehydrogenase/reductase (SDR) family, with NAD(P)-binding and NADPH-dependent carbonyl reductase, L-xylulose reductase, sorbose reductase, and mannitol 2-dehydrogenase activities. The gene is associated with ethanol and ethanal metabolism, xylulose and mannitol metabolism, L-sorbose breakdown, cellular respiration, and electron transfer. It is linked to nuclear division, meiosis II, transcription by RNA polymerase II, translation termination and initiation, and protein homotetramerization. The product localizes to the cytosol and nucleus. Studies of related genes in other species connect the family to EC 1.1.1.184 and EC 1.1.1.289 activities.