DBP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC212.11 (DBP2, also known as tlh1) on chromosome 1 of Schizosaccharomyces pombe encodes a DEAD/DEAH-box helicase with four-way junction helicase activity, 3'-5' DNA helicase activity, RNA helicase activity, and ATP hydrolase activity, and binds nucleic acids, ATP and zinc. The protein localises to the nucleolus, cytoplasm, nuclear replication forks and telomeric repeat regions, and is associated with meiotic prophase I, resolution of recombination intermediates, alternative mRNA splicing, nonsense-mediated mRNA decay, rDNA maintenance, replication fork arrest, DNA double-strand break processing, and the response to UV-A. Phenotype associations link the gene to mitotic recombination, sporulation efficiency, cell cycle progression through G1/S and G2/M transitions, chromosome segregation, vegetative growth, thermotolerance, gamma ray resistance, and carbon source utilisation. Studies of related genes in other species connect the family to oxidative stress response.