rad57 — Schizosaccharomyces pombe 972h-

Summary

SPAC20H4.07, the rad57 gene on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a recombinase with ATP hydrolase activity, ATP-dependent DNA damage sensor activity, and ATPase inhibitor activity. It binds single- and double-stranded DNA, identical proteins, and the Sae3-Mei5 complex. Rad57 is associated with recombinational repair, meiotic and mitotic recombination, double-strand break repair during meiotic recombination, meiotic strand invasion and joint molecule formation, gene conversion, mating-type switching, replication fork processing, and mitotic S phase. It localises to the nucleus, chromatin, nuclear envelope, condensed nuclear chromosome, centromere complex, CX3 complex, and sites of double-strand breaks. Related genes in other species are linked to recombinational interstrand cross-link repair and stalled replication fork localisation to the nuclear periphery.