fus1 — Schizosaccharomyces pombe 972h-

Summary

SPAC20G4.02C (fus1) on chromosome 1 of Schizosaccharomyces pombe encodes a formin family protein containing actin filament regulator, FH2, GBD/FH3, and GTPase-binding domains. The gene product binds F-actin, small GTPases, SH3 domains, F-BAR domains, and cytoskeletal proteins. Fus1 is associated with cell-cell fusion, syngamy, karyogamy, cytogamy, actin fusion focus formation, actin nucleation, barbed-end actin filament capping, actin filament bundle organization and assembly, protein localization to the mitotic actomyosin contractile ring, Golgi localization, cellular bud site selection, regulation of cell shape, establishment or maintenance of bipolar cell polarity, meiosis II, and neurotransmitter release. It localizes to the mating projection, mating projection actin fusion focus, neck ring, medial cortex septin ring, cellular bud neck split septin rings, Spitzenkorper, midsome, actomyosin contractile ring proximal layer, and cell cortex of growing cell tip. Studies of related genes in other species link the family to actin organization and cell polarity.