ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC20H4.06C, designated SpARK1 (also known as SpPRK1) on Schizosaccharomyces pombe chromosome 1, encodes an uncharacterized protein containing a DUF1604 domain. The product exhibits protein binding, bridging and RNA binding activities. SpARK1 is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome biorientation, chromosome condensation, telophase, meiosis II, and the spindle checkpoint. It is also linked to TORC2 signaling, microtubule shortening, cellular homeostasis, and flocculation. The protein localizes to the nucleus, cytosol, and spliceosome complex. Phenotypic associations include delayed cell cycle progression in G2 phase, arrested S phase, decreased cytokinesis, endocytosis, and mating type switching, abnormal filamentous and pseudohyphal growth, increased polyploidy, and decreased necrotic cell death. Studies of related genes in other species connect the family to cell membrane stability and protein content.