SPT6 — Schizosaccharomyces pombe 972h-

Summary

SPT6 (SPAC1F7.01C) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with DNA binding transcription antitermination factor activity, H3-H4 histone carrier activity, nucleosome binding, histone binding, and DNA binding. It is a member of the Spt6 protein family, containing SH2, HTH, and YqgF/RNaseH-like domains. The gene is associated with transcription elongation by RNA polymerase II, lncRNA transcription, nucleosome organization and assembly, co-transcriptional chromatin reassembly, mRNA 3'-end processing, and mRNA export. It is linked to cell cycle progression through G1/S and G2/M transitions, meiosis, filamentous growth in response to starvation and biotic stimulus, cellular responses to stress and starvation, and increased transposable element transposition. Localization evidence connects SPT6 to the nucleus, euchromatin, centric heterochromatin, and the transcription elongation factor complex. Studies of related genes in other species link the Spt6 family to unaffected pathogenicity and fusarium ear blight.