ORLA — Schizosaccharomyces pombe 972h-

Summary

SPAC19G12.15C (ORLA, also known as tpp1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with trehalose-phosphatase, trehalose synthase, and transglucosylase activities, belonging to the Glyco_trans_20 and trehalose-PPase domain families. The gene is associated with mycose biosynthesis and metabolism, cellular responses to desiccation, heat, and stress, as well as filamentous growth in response to heat and biotic stimuli. It is linked to ascospore formation, telomere localization and maintenance, DNA repair and damage checkpoint, sumoylation, nuclear export, and fungal-type cell wall organization. The product localizes to the cytosol, nucleus, and trehalose-6-phosphate synthase complex. Phenotypic associations include increased acquired thermotolerance and freeze-thaw resistance, increased entry into G0 and survival in stationary phase, increased polyploidy and mutation frequency, decreased nuclear size, delayed meiosis, absent spore germination, and altered mating response, pexophagy, and cell cycle progression.