cid1 — Schizosaccharomyces pombe 972h-

Summary

SPAC19D5.03 (cid1) on chromosome 1 of Schizosaccharomyces pombe encodes a poly(U) polymerase (EC 2.7.7.52) belonging to the PAP-associated and MTPAP-like central domain families. The enzyme exhibits RNA adenylating activity, binds UTP, ATP, RNA, and metal ions, and localises to the nucleus, nucleolus, cytoplasm, cytosol, mitochondria, and the TRAMP complex. Cid1 is associated with polyuridylation-dependent decapping and catabolism of nuclear-transcribed mRNA, snoRNA breakdown, mitochondrial RNA catabolism, and siRNA catabolic processes. It is linked to negative regulation of nuclear-transcribed mRNA poly(A) tail shortening and gene expression, DNA integrity checkpoint signalling, establishment of sister chromatid cohesion, and RNA surveillance. The gene is also connected to 3'-UTR-mediated mRNA stabilisation, priRNA 3'-end processing, and U4 snRNA 3'-end processing. Related genes in other species encode polynucleotide adenylyltransferases.