pyp2 — Schizosaccharomyces pombe 972h-

Summary

pyp2 (SPAC19D5.01) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a protein tyrosine phosphatase with MAP kinase tyrosine phosphatase activity (EC 3.1.3.48). The product belongs to the protein-tyrosine phosphatase family and contains a rhodanese-like domain. This gene is associated with the regulation of mitosis, including positive regulation of mitotic entry and mitotic exit, as well as downregulation of mitosis. It is linked to stress-activated MAPK cascades, the cell integrity MAPK cascade, and responses to arsenic, glucose, and osmotic stress. Additional associations include mRNA destabilization, the glyoxylate cycle, nuclear transport, and regulation of cell growth. The protein localizes to the cytoplasm, cytosol, nucleus, mitochondria, and protein aggregate centers. Studies of related genes in other species further connect this gene family to MAPK pathway regulation.