rad1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1952.07 (rad1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with nuclease and hydrolase activity that binds damaged DNA and double-stranded DNA. The product belongs to the Rad1/Rec1/Rad17 and DNA clamp superfamilies, and is a component of the cell cycle checkpoint Rad1 family. This gene is associated with DNA integrity checkpoint control, response to radiation, resolution of recombination intermediates, strand displacement, and regulation of DNA repair. It is linked to meiotic prophase I, spermatogenesis, establishment of sister chromatid cohesion, telomere capping, replication fork arrest, and both meiotic G2/MI and mitotic G2 DNA damage checkpoints. The protein localises to the nucleus, cytoplasm, cytosol, chromosome telomeric repeat region, and sites of double-strand breaks. Related genes in other species link the family to DNA repair exonuclease activity.