FOR — Schizosaccharomyces pombe 972h-

Summary

SPAC18G6.04C (FOR, shm2) on chromosome 1 of Schizosaccharomyces pombe encodes a serine hydroxymethyltransferase, an enzyme with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, classified as EC 2.1.2.1. The gene is associated with tetrahydrofolate metabolism and interconversion, pore formation, abscission, Golgi localization, actin nucleation, nuclear pore complex assembly, G2 phase, nuclear transport, deubiquitination, heme anabolism, cell polarization, chromatin silencing, ERAD pathway, and nitric oxide storage. It is linked to the fungal biofilm matrix, mitochondria, cytoplasm, and cytosol. Phenotypic associations include arrested meiosis, decreased S-phase progression, absent respiratory metabolism, abnormal plasma membrane morphology, increased chromosome maintenance, decreased prion inheritance, absent budding, increased critical cell size at G1 start, premature metaphase and telophase progression, increased fermentative metabolism, decreased colony size, and abnormal cytokinesis. Related genes in other species are linked to nutrient utilization and turgor pressure.