GCN5 — Schizosaccharomyces pombe 972h-

Summary

SPAC1952.05 (GCN5) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with GNAT and bromodomain motifs, classified as EC 2.3.1.48. The product possesses histone H3K9, H3K14, H3K18 and H4K16 acetyltransferase activities, functions as a histone reader for H3K56ac, H4K12ac and H4K16ac, and acts as a promoter-specific chromatin-binding transcriptional co-regulator. GCN5 is associated with the ADA, SALSA and SAGA complexes, localises to chromatin, centromeres and heterochromatin, and is linked to chromosome condensation, heterochromatin boundary formation, DNA repair-dependent chromatin remodelling, the spindle assembly checkpoint, karyogamy, septin ring assembly, and responses to nutrients and osmotic stress. The gene is also connected to polyamine and nicotinamide metabolism, iron-sulfur cluster assembly, embryogenesis, and regulation of protein stability. Studies of related genes in other species link the family to virulence and oxidative stress responses.