BIM1 — Schizosaccharomyces pombe 972h-

Summary

SPAC18G6.15 (BIM1, mal3) on chromosome 1 of Schizosaccharomyces pombe encodes a protein of the MAPRE family, containing CH and EB1_C domains, with cytoskeletal adaptor activity, microtubule plus-end and lateral binding, ATPase activator activity, and phase separation nucleator activity. The gene is associated with microtubule dynamics, including nucleation, destabilization, polymerization regulation, and plus-end localization, as well as microtubule-based transport, protein localization to microtubules, centromere localization, nuclear congression, karyogamy, spindle checkpoint, mitotic spindle assembly, and attachment of spindle microtubules to chromosomes. It is linked to telophase progression, nucleus organization, and downregulation of phosphorylation. Phenotypic associations include altered cell cycle progression (G1/S delay, premature metaphase-anaphase transition, G2 arrest), increased mating efficiency, abnormal nuclear fusion during mating, delayed sporulation, increased hydrostatic pressure resistance, increased fermentative growth, and decreased colony sectoring.