CSH1 — Schizosaccharomyces pombe 972h-

Summary

SPAC17G8.11C (CSH1, imt3) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes an IPC mannosyltransferase 3, a glycosyltransferase-domain protein with inositol phosphorylceramide mannosyltransferase and mannosyltransferase activity. This gene is associated with MIPC biosynthetic process, constitutive heterochromatin assembly, PTGS, chromatin silencing, demethylation, methylation, nucleosome organization, chromatin remodeling, mitosis, anaphase, morphogenesis, and endocytosis. It localizes to the cis- and trans-Golgi network membrane, Golgi complex, and ER membrane. Phenotypic associations include decreased autophagy and pexophagy rates, absent flocculation and cell fusion, decreased cell cycle progression and hypoosmotic stress resistance, increased fermentative growth and freeze-thaw resistance, abnormal prion inheritance and formation, and delayed vacuolar transport and endocytosis. Related genes in other species link the family to acid sensitivity and oxidative stress response.