pck1 — Schizosaccharomyces pombe 972h-

Summary

SPAC17G8.14C (pck1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein kinase C with serine/threonine kinase activity, lipid binding, and zinc binding capabilities, classified under EC 2.7.11.13. The product contains C2, HR1, and protein kinase domains. This gene is associated with the regulation of cell shape, cell integrity MAPK cascade, actin cytoskeleton organization, and mitotic cytokinesis site selection. It is linked to alpha-glucan anabolism, response to glucose, downregulation of glucose-mediated signalling, and programmed cell death. The protein localizes to the actomyosin contractile ring, division septum, cell tips, stress granules, and sites of polarized growth. Studies of related genes in other species connect the family to cell wall biosynthesis and pathogenicity, though these associations are not established for pck1 itself.