FRH — Schizosaccharomyces pombe 972h-

Summary

SPAC17H9.02 (symbol FRH, also known as mtl1) on chromosome 1 of Schizosaccharomyces pombe encodes an uncharacterized helicase belonging to the SKI2-like and MTR4-like families, with RNA helicase, ATP hydrolase, nucleic acid and RNA binding activities. The gene is associated with diverse RNA-related processes including polyadenylation-dependent noncoding RNA catabolism, sno(s)RNA processing, siRNA catabolism, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, and maturation of 5.8S rRNA. It is also linked to constitutive heterochromatin assembly, heterochromatin island assembly, HOOD assembly, and beta-glucan anabolism. The encoded product localizes to the spliceosome, Ski complex, RQT complex, nucleolus, and nuclear body. Phenotypic associations include abnormal cell cycle progression, chromosome segregation defects, abnormal cell size and nuclear position, and changes in respiratory metabolism and redox state. Related genes in other species link the family to the TRAMP complex.