CDCA — Schizosaccharomyces pombe 972h-

Summary

SPAC1782.09C, also known as CDCA or clp1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a dual-specificity phosphatase (EC 3.1.3.48) with protein tyrosine/serine/threonine phosphatase activity, belonging to the CDC14 family. The gene is associated with multiple cell cycle processes, including mitotic prometaphase, telophase, spindle midzone assembly, spindle breakdown, and meiotic spindle breakdown. It is linked to regulation of cell septum assembly, upregulation of cytokinesis and septation initiation signaling, chromosome biorientation, and the mitotic cytokinesis and spindle assembly checkpoints. Additional associations include ciliogenesis, negative regulation of RNA polymerase I transcription, rDNA packaging, cell fate determination, and protein dephosphorylation. The product localizes to the RENT complex, mitotic spindle midzone, actomyosin contractile ring, spindle pole body, and primary cell septum. Phenotypic associations include temperature-sensitive growth, cell cycle progression alterations, absent septum formation, and increased polyploidy.