YAP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1783.07C, also known as YAP1 or pap1, encodes a bZIP transcription factor on chromosome 1 of Schizosaccharomyces pombe 972h-. The product contains an AP-1-like domain and a Yap1 redox domain superfamily, and has DNA-binding transcription activator activity specific for RNA polymerase II. It is associated with responses to oxidative and nitrosative stress, methylglyoxal, singlet oxygen, and lipid oxidation, as well as with ferroptosis, glucose detection, and redox sensing. The protein localizes to the nucleus, cytoplasm, chromatin, and transcription regulator complexes. YAP1 is linked to calcium sensitivity and the oxidative stress response, and to processes including sexual sporulation, spindle pole body separation, and regulation of emericellin and asperthecin. Studies of related genes in other species connect the family to virulence traits.