ARK1 — Schizosaccharomyces pombe 972h-

Summary

The fission yeast gene SPAC17D4.01 (symbol ARK1, preferred name pex7) encodes a WD40-repeat protein with PTS2 binding, histone acetylase activity, and protein-binding bridging functions. It is associated with peroxisome matrix protein import and docking, protein-peroxisome targeting, and localizes to the peroxisomal lumen and membrane. The gene is also linked to chromosome segregation, kinetochore assembly, centrosome duplication, and TORC2 signaling. Phenotypic associations include decreased cytokinesis, delayed G2 phase cell cycle progression, abnormal filamentous and pseudohyphal growth, decreased mating-type switching, increased polyploidy, and decreased necrotic cell death. Studies of related genes in other species link the family to cell membrane stability, protein content, and phosphate content traits, as well as loss of pathogenicity and reduced virulence.