nuc2 — Schizosaccharomyces pombe 972h-

Summary

SPAC17C9.01C (nuc2, also known as CDC27) on chromosome 1 of Schizosaccharomyces pombe encodes a tetratricopeptide repeat (TPR)-containing protein with enzyme-substrate adaptor activity and DNA binding. The gene is associated with mitotic metaphase and anaphase, chromosome condensation and separation, spindle elongation, and the metaphase-to-anaphase transition. It is linked to the anaphase-promoting complex-dependent catabolic process, entry into the meiotic cell cycle, and cellular response to stress. Phenotypic associations include arrested cell cycle progression at multiple stages (G2, metaphase-anaphase transition, anaphase, telophase), absent chromosome segregation and meiotic recombination, increased polyploidy, decreased meiosis and UV resistance, and abnormal spore wall formation. The protein localises to the cyclosome, mitotic spindle pole body, cell division site, cytoplasm and nucleus.