mis6 — Schizosaccharomyces pombe 972h-

Summary

SPAC1687.20C, symbol mis6 on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes the CENP-I family protein Mis6. This product localizes to the inner kinetochore, centromeric core domain, and centromere complex. Mis6 is associated with a broad range of mitotic and meiotic processes, including kinetochore organization and assembly, centromere separation and clustering, chromosome segregation, spindle checkpoint function, and CENP-A-containing chromatin assembly. It is also linked to microtubule dynamics, spindle attachment, centromeric silencing, and RNA splicing. During the cell cycle, the gene has been connected to interphase, G2 phase, and prophase. Related genes in other species are associated with the Sim4 complex.