CDC48 — Schizosaccharomyces pombe 972h-

Summary

SPAC1565.08 (CDC48) on chromosome 1 of Schizosaccharomyces pombe encodes an AAA-family ATPase with ATP-dependent protein disaggregase and protein transporter activities, and is classified as EC 3.6.4.6. The gene is associated with mitotic anaphase and metaphase progression, spindle breakdown, and cell cycle control through G1/S and G2 phases. It is linked to desumoylation and sumoylation, nuclear protein quality control via the ubiquitin-proteasome system, protein dislocation from the endoplasmic reticulum, and ribosome-associated ubiquitin-dependent protein breakdown. CDC48 is also associated with peroxisome matrix protein import and receptor recycling, Golgi localization, vesicle fusion, and activation of the cellular response to hypoxic stress. Phenotypic associations include altered entry into stationary phase, abnormal mitophagy, decreased chronological lifespan, increased fermentative growth, and resistance to chemicals.