rad50 — Schizosaccharomyces pombe 972h-

Summary

SPAC1556.01C (rad50) in Schizosaccharomyces pombe 972h- encodes a Rad50 protein, a component of the MRN complex that possesses ATP hydrolase, DNA helicase, and DNA end-binding activities, and binds double-stranded, single-stranded, and G-DNA. The gene is associated with DNA double-strand break processing and repair, including meiotic recombination, strand invasion, and gene conversion at the mating-type locus. It is linked to telomere maintenance via telomerase, replication fork arrest and stalled fork localization to the nuclear periphery, and mitotic recombination-dependent fork processing. The product localizes to the MRN complex, chromatin, condensed nuclear chromosomes, and sites of double-strand breaks. Rad50 is also associated with responses to bleomycin, ionizing radiation, and hydroxyurea, as well as cell cycle phase, prophase, karyogamy, and protein positioning.