SSA1 — Schizosaccharomyces pombe 972h-

Summary

SSA1 (SPAC13G7.02C) on chromosome 1 of Schizosaccharomyces pombe encodes a member of the Hsp70 family of heat shock proteins, characterised by an ATPase nucleotide-binding domain and a peptide-binding domain, with ATP hydrolase activity, peptide binding, heat shock protein binding, and protein folding chaperone functions, and it also acts as a transcriptional co-regulator. The gene is associated with diverse biological processes including protein refolding, proteasome assembly, microtubule assembly, nuclear import, mRNA metabolism, cell fate specification, sexual reproduction, the TCA cycle, and sterol anabolism. It is linked to the oxidative stress response and numerous phenotypes such as increased thermotolerance, premature apoptosis, altered cell cycle progression, abnormal spore germination, increased polyploidy, and altered prion inheritance. The protein localises to the cytoplasm, membrane, cell wall, and protein aggregate centres.