MAD1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1486.04C, also known as MAD1, alm1, MLP1, SpMLP1 or SpMAD1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a structural constituent of the nuclear pore. The gene is associated with the mitotic spindle checkpoint, spindle assembly checkpoint, MCC assembly, positive regulation of recombination-dependent DNA replication, proteasome localization, spindle orientation, centromere localization, microtubule dynamics, mRNA-nucleus export, actin polymerization, and protein nucleus import. It localizes to the nuclear pore nuclear basket, nuclear periphery, nuclear envelope, cytoplasm, and nucleus. Phenotypic associations include abnormal cell cycle progression in M phase, arrested G2 phase, arrested metaphase-anaphase transition, delayed meiosis, absent spore germination, increased polyploidy and aneuploidy, decreased nuclear fusion during mating, and decreased nucleophagy. Related genes in other species link it to nuclear pore basket structure and mRNA export.