CHA4 — Schizosaccharomyces pombe 972h-

Summary

SPAC11D3.11C (SpCHA4) on chromosome 1 of Schizosaccharomyces pombe encodes a Zn2Cys6 DNA-binding domain transcriptional regulatory protein with RNA polymerase II-specific transcription factor activity. The gene is associated with diverse cellular processes including monopolar cell growth, microtubule dynamics and stabilization, actin depolymerization, spore wall assembly, nitrogen utilization, and the septation initiation network (SIN). It is linked to appressorium formation, DNA replication checkpoint control, and positive regulation of transcription initiation. Phenotypic associations include abnormal cell size and budding patterns, delayed or arrested cell cycle progression through G1, G2, and metaphase, decreased spore germination, abnormal sporulation, and altered nitrogen and carbon source utilization. The protein localizes to both the nucleus and cytosol. Studies of related genes in other species connect the family to nuclear morphology and nucleolar size.