PRP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC10F6.02C (PRP2) in Schizosaccharomyces pombe 972h- encodes a DEAH-box RNA helicase with 3'-5' RNA helicase activity, ATP binding and hydrolysis, and dsRNA and mRNA binding. The product localises to spliceosomal complexes, the nucleolus, and chromatin. PRP2 is associated with spliceosome disassembly, catalytic spliceosome formation, and mRNA splicing via the spliceosome, as well as rRNA maturation, cytoplasmic translational initiation, and positive regulation of RNA polymerase I transcription. It is linked to chromosome separation, nuclear division, cell cycle control, S phase progression, and meiosis. Phenotypic associations include abnormal carbon source utilisation, delayed chromosome segregation, increased X-ray resistance, altered mating efficiency and shmoo formation, and defects in cell cycle progression through G2/M and S phases. Studies of related genes in other species connect it to RNA helicase function and spliceosome dynamics.