swi2 — Schizosaccharomyces pombe 972h-

Summary

SPAC1142.03C, the swi2 gene on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein with sequence-specific double-stranded DNA binding activity. The gene is associated with mating-type switching, gene conversion at the mating-type locus, and donor selection, as well as meiotic prophase I, meiosis I, and sex determination. It is linked to heterochromatin organization, chromatin silencing, and structural organization, and localizes to the mating-type region heterochromatin, nucleolus, and nucleus. Additional associations include recombinational repair, TC-NER, transposition, spindle checkpoint, sumoylation, osmotic response, and M phase. Related genes in other species further connect the Swi5-Swi2 complex to these processes.