for3 — Schizosaccharomyces pombe 972h-

Summary

SPCC895.05 (for3) in Schizosaccharomyces pombe 972h- on chromosome 3 encodes a formin protein, a member of the FH2 domain family that acts as an actin filament regulator. The gene product binds F-actin, small GTPases, SH3 domains, and F-BAR domains, and is associated with cytoskeletal protein binding. For3 is associated with symmetric cell division, protein localization to the mitotic actomyosin contractile ring, exocyst and Golgi localization, cytogamy, actin filament bundle organization and assembly, barbed-end actin filament capping, membrane assembly and biogenesis, microtubule dynamics, contractile ring assembly, actin cortical patch localization, meiosis II, regulation of cell shape, establishment or maintenance of bipolar cell polarity, and cellular bud site selection. It localizes to the cell cortex of growing cell tips, mating projections, the actomyosin contractile ring, and septin rings at the bud neck. Studies of related genes in other species link the family to similar actin-mediated processes.