ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1006.02 (ARK1, also known as asa1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein containing WD40 repeat domains. The gene is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, and chromosome biorientation. It is also linked to TORC2 signaling, microtubule shortening, meiosis II, telophase, and galactose-specific flocculation. The protein localizes to the nucleus, cytosol, and the TTT complex. Phenotypic associations include delayed cell cycle progression in G2 phase, arrested S phase, decreased cytokinesis, abnormal filamentous and pseudohyphal growth, altered mating-type switching, increased polyploidy, decreased pheromone sensitivity, and reduced necrotic cell death. Studies of related genes in other species connect the family to cell membrane stability and protein content.