CAT1 — Schizosaccharomyces pombe 972h-

Summary

SPCC757.07C, also known as CAT1 or ctt1, encodes a catalase enzyme (EC 1.11.1.6) with catalase activity and heme binding, belonging to the catalase clade 1/3 family. The gene is associated with hydrogen peroxide metabolic and catabolic processes, cellular detoxification of hydrogen peroxide, and responses to hydrogen peroxide, salt, and glucose. It is linked to sexual sporulation, flocculation, siderophore and indole alkaloid anabolism, ubiquinone anabolism, and amino acid import. The catalase localizes to the peroxisomal lumen, mitochondria, cytoplasm, and fungal-type cell wall. Phenotypic associations include increased pexophagy, increased ionic stress resistance, increased starvation resistance, increased entry into G0 phase, increased meiotic recombination, and increased mitochondrial rho- mutation frequency, alongside decreased fermentative metabolism, decreased anaerobic growth, decreased mating response, and sterility. Studies of related genes in other species link the family to reduced virulence.