mmi1 — Schizosaccharomyces pombe 972h-

Summary

SPCC736.12C (mmi1) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a YTH-domain-containing protein. The gene product has N6-methyladenosine-containing RNA reader activity and protein-RNA adaptor activity, and binds pre-mRNA introns, mRNA 3'-UTRs, lncRNA, and the CCR4-NOT complex. It localises to the nucleus, cytoplasm, chromatin, heterochromatin islands, and the Mei2 dot. Mmi1 is associated with nuclear RNA surveillance, including lncRNA breakdown, polyadenylation-dependent CUT catabolism, and regulation of heterochromatin island assembly. It is linked to meiotic S phase, rRNA modification and 2'-O-methylation, RNA stabilisation and destabilisation, and HOOD and fHC assembly. The protein has also been connected to vision and to the regulation of termination of RNA polymerase II transcription.