ctp1 — Schizosaccharomyces pombe 972h-

Summary

SPCC338.08 (ctp1) in Schizosaccharomyces pombe 972h- encodes the Ctp1 protein, a member of the SAE2 family containing a Ctp1_C domain. The product possesses endodeoxyribonuclease activator activity and hydrolase activity, binds to various DNA structures including double-strand/single-strand junctions, bubble, flap, and Y-form DNA, and exhibits endonuclease activity. Ctp1 is associated with DNA double-strand break processing, meiotic recombination, recombinational repair, and non-homologous end joining (NHEJ). It is linked to the response to bleomycin, replication fork processing, stalled replication fork localization to the nuclear periphery, gene conversion at the mating-type locus, and cell cycle checkpoint control including the S-M checkpoint and DNA damage checkpoint. The protein localizes to the nucleus and to sites of double-strand breaks.