rad21 — Schizosaccharomyces pombe 972h-

Summary

SPCC338.17C (rad21) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with Rad21/Rec8-like domains, including a winged helix DNA-binding domain, and is a component of the mitotic cohesin complex. The gene is associated with chromatin binding and the maintenance of sister chromatid cohesion, as well as mitotic cell cycle stages including metaphase, anaphase, and S phase. It has been linked to meiotic processes such as leptotene, zygotene, pachytene, diplotene, and diakinesis, and to nucleus organization, replication-born double-strand break repair by sister chromatid exchange, and the response to hydroxyurea. Associations also include pollen development, embryogenesis, cell maturation, and regulation of programmed cell death. The protein localises to chromatin, the nucleolus, subtelomeric regions, heterochromatin islands, and centric heterochromatin. Related genes in other species are linked to double-strand break repair.