SET9 — Schizosaccharomyces pombe 972h-

Summary

SPCC4B3.12 (SET9) in Schizosaccharomyces pombe 972h- encodes the histone methyltransferase Kmt5, which catalyses histone H4K20 trimethylation (EC 2.1.1.372) and belongs to the Suv4-20/Set9 family. The gene product is associated with histone and nucleosome binding, and is linked to chromatin, the nucleus, the mitotic spindle pole body, and the cell division site. SET9 has been associated with DNA damage response and checkpoint control, homologous recombination, strand invasion, cell cycle regulation, and gene expression. Studies of related genes in other species link the family to reduced virulence and fusarium head blight, though these associations are not established for S. pombe.