SET1 — Schizosaccharomyces pombe 972h-

Summary

SPCC306.04C (SET1) encodes a histone H3K4 trimethylase (EC 2.1.1.354) and belongs to the Set1-like protein family, containing SET, post-SET, and RNA-recognition motif domains. The gene product is a core component of the COMPASS/Set1C complex and localises to chromatin, telomeric regions, and the nucleus. SET1 is associated with heterochromatin organisation, transposable element silencing, regulation of meiotic DNA double-strand break formation, mating-type switching, donor selection, gene conversion, and sterol homeostasis. It is linked to cell cycle progression through G2/M and G1/S transitions, metaphase-anaphase timing, sporulation, pheromone sensitivity, nuclear export, and exit from G0. Studies of related genes in other species link the family to reduced virulence.