MIP1 — Schizosaccharomyces pombe 972h-

Summary

SPCC24B10.22 (symbol MIP1, also known as pog1) on chromosome 3 of Schizosaccharomyces pombe encodes a DNA-directed DNA polymerase with 3'-5' exonuclease activity, belonging to the DNA-directed DNA polymerase A family and the gamma DNA polymerase complex. The gene is associated with mitochondrial DNA replication, sumoylation and desumoylation, TOR signaling, oxidative phosphorylation, cell cycle control including G1 phase, mitosis and meiosis, and responses to nutrients and stimuli. It has been linked to traits such as oxidative stress response and numerous phenotypes including altered cell cycle progression, increased or decreased mutation frequency, abnormal mitochondrial genome maintenance and morphology, increased UV resistance, decreased gamma ray resistance, decreased sporulation efficiency, and reduced viability. Studies of related genes in other species connect the family to mitochondrial genome maintenance and respiratory metabolism.