MYO2 — Schizosaccharomyces pombe 972h-

Summary

SPCC1919.10C (MYO2, myo52) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with myosin head motor domain, myosin N, dilute domain, IQ motif, and kinesin motor domain superfamily features, and has calcium-dependent ATPase activity, microfilament motor activity, calmodulin binding, F-actin binding, small GTPase binding, and ATP binding. It is associated with actin filament bundle retrograde transport, vesicle transport along actin filaments, endomembrane organization, Golgi division, peroxisome inheritance, spindle pole body separation, centromere separation, abscission, organelle inheritance, nuclear migration during mitotic telophase, and cell motility. The gene is linked to salt response and numerous phenotypes including delayed nuclear fusion during mating, absent or decreased septum formation, increased mating type switching, abnormal Golgi and vacuolar distribution, delayed vacuolar and protein transport, absent peroxisomal transport, abnormal endoplasmic reticulum distribution, and altered cell cycle progression through G2/M phase transition. It localizes to the myosin V complex, formin-nucleated actin cables, cortical cytoskeleton, and transport vesicles.