TEL1 — Schizosaccharomyces pombe 972h-

Summary

SPCC23B6.03C (TEL1) in Schizosaccharomyces pombe 972h- on chromosome 3 encodes a serine/threonine-protein kinase with histone H2A kinase activity, small GTPase binding, and ATP binding, belonging to the PIKK family with ATM-related domains. The gene is associated with telomere capping, DNA damage checkpoint control, replication fork arrest, non-homologous end joining, homologous recombination repair, gene conversion, programmed cell death, and regulation of meiotic double-strand break formation. It is linked to cell cycle checkpoint function, G1 phase regulation, intracellular signal transduction, and DNA metabolism. Localisation evidence connects the product to the nucleus, chromosome telomeric region, and cytosol. The gene has also been associated with respiration rate. Studies of related genes in other species link the family to lethality and associations with Fusarium ear blight and Verticillium dahliae infection, though these are not established for S. pombe.