RTS1 — Schizosaccharomyces pombe 972h-

Summary

SPCC188.02, also known as RTS1 or par1 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a protein with protein phosphatase activator activity and protein binding, bridging functions. The product belongs to the PP2A_B56 family and contains ARM-like domains. This gene is associated with numerous cell cycle processes, including site-specific DNA replication termination, meiotic sister chromatid cohesion, mitotic G1 cell size control, spindle checkpoint function, and mating type switching. It localizes to the PP2A complex, inner kinetochore, meiotic spindle, centromere complex, mitotic actomyosin contractile ring, and mitotic spindle pole body. Phenotypic associations link RTS1 to altered cell cycle progression, decreased autophagy and pexophagy rates, abnormal sporulation efficiency, increased prion inheritance, and absent resistance to X-ray and alkaline pH stress. Studies of related genes in other species connect the family to potassium concentration and oxidative stress response.