ABCA — Schizosaccharomyces pombe 972h-

Summary

SPCC18B5.01C (symbol bfr1, also known as ABCA) on chromosome 3 of Schizosaccharomyces pombe encodes an ATP-binding cassette (ABC) transporter with ATP-coupled transmembrane transporter activity and ATP hydrolase activity. The protein belongs to the PDR/CDR family of ABC transporters and localises to the plasma membrane. The gene is associated with negative regulation of the cell cycle, division plane positioning, microtubule dynamics, and contractile ring assembly. It is linked to phytochelatin transport, response to radiation, response to antibiotic, and response to iron. Associations with traits include protein content and oxidative stress response. Phenotypic associations involve abnormal small molecule transport, altered vacuolar distribution and transport, increased sporulation rate, decreased cell death rate, increased fermentative growth, and delayed exit from stationary phase. Related genes in other species link the family to multidrug resistance and pathogenicity.