cds1 — Schizosaccharomyces pombe 972h-

Summary

SPCC18B5.11C (cds1, also known as SpRAD53) on chromosome 3 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with calcium/calmodulin-dependent and protein kinase A activities, containing an FHA domain and a protein kinase domain. The gene is associated with DNA integrity checkpoint control, response to ionizing radiation, UV, cisplatin, and hydroxyurea, as well as mitotic S phase, pachytene, microtubule stabilization, and positive regulation of reciprocal meiotic recombination. It localizes to the linear element, perinuclear space, nuclear membrane, and cellular bud neck. Phenotypic associations include altered cell cycle progression rates across G1, S, G2, and M phases, absent X-ray resistance, increased gamma ray resistance, increased sporulation rate, and abnormal pheromone-induced cell cycle arrest. Related genes in other species link the family to lethality.