ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPCC16C4.11, also known as ARK1 or pef1, encodes a cyclin-dependent protein kinase (CDK) with serine/threonine kinase activity, belonging to the CDK and protein kinase domain families. It binds cyclin, RNA polymerase II core, histone, and ATP, and is classified under EC 2.7.11.22. In Schizosaccharomyces pombe, this gene is associated with the regulation of chromosome segregation, centrosome duplication, mitotic DNA integrity checkpoint signaling, and meiotic DNA replication checkpoint processes. It is also linked to negative regulation of primary cell septum biogenesis, positive regulation of glycogenolysis, and galactose-specific flocculation. The protein localizes to the Pho85-Pho80 CDK-cyclin complex, spindle pole bodies, and meiotic spindles. Phenotypic associations include delayed G2 phase cell cycle progression, decreased cytokinesis, abnormal filamentous growth, and increased polyploidy.